Tankyrase Inhibitors (TNKS) 49 Size:Contact [email protected] for quotation 19)20)5-4-10-15(14)9(17)6-13(23)21-10/h4-6H

19)20)5-4-10-15(14)9(17)6-13(23)21-10/h4-6H

InChi: InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6

fumarate reductase

N-dihexylacetamide

Tankyrase Inhibitors (TNKS) 49 Size:Contact [email protected] for quotation 19)20)5-4-10-15(14)9(17)6-13(23)21-10/h4-6HTankyrase Inhibitors (TNKS) 49 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis