MCHR1 antagonist 2 ursor PLX647 also inhibits endogenous FMS

PLX647 also inhibits endogenous FMS and KIT

The modulatory effect of Kavain is moderate

[Epub ahead of print] PubMed PMID: 24998846

4 µM for HDAC1)

MCHR1 antagonist 2 ursor PLX647 also inhibits endogenous FMSMCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4. 0 nM in IMR 32 cells. Product information CAS Number: 863115 70 2 Molecular Weight: 424. 42 Formula: C23H21FN2O5 Chemical Name: N {1 [(2H 1,3 benzodioxol 5 yl)methyl]piperidin 4 yl} 6 fluoro 4 oxo 4H chromene 2 carboxamide Smiles: O=C1C=C(OC2=CC=C(F)C=C12)C(=O)NC1CCN(CC2C=C3OCOC3=CC=2)CC1