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Molecular Weight: 207
27)23-7-9-28-10-8-23/h2-6
Molecular Weight: 595
PMID: 5852321
BIX 02189 - CAS# 1265916-41-3 122 Molecular Weight: 207BIX 02189, CAS No. 1265916 41 3, is a selective MEK5 ERK5 inhibitor with an IC50 of 59 nM. BIX02189 was reported to inhibit catalytic function of purified, MEK5 enzyme. BIX02189 blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1 2 in sorbitol stimulated HeLa cells. BIX02189 also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5 ERK5 signaling cascade, in a cellular trans reporter assay system.
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