IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 0232 Smiles: O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1

Smiles: O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1

CAS Number: 147591-46-6

MM-102 specifically reduces expression of two critical MLL1 target genes (HoxA9 and Meis-1)

Molecular Weight: 328

IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 0232 Smiles: O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1IDH C227, CAS No. 1355324 14 9, is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0. 1 M, and 2 HG production in HT1080 and U87MG cells with IC50 < 0. 25 M. Because the mutated form of IDH1 produces the metabolite, 2 hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of