WH-4-023 denafil Hydrochloride 2012(5):9–20

2012(5):9–20

Chemical Name: 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline

Molecular imaging of the ATM kinase activity

1 100 PMID: 30271980

WH-4-023 denafil Hydrochloride 2012(5):9–20WH 4 023 is a potent and selective dual Lck Src inhibitor with IC50 of 2 nM 6 nM for Lck and Src kinase respectively. The lymphocyte specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Product