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13(9):1070-5
) significantly delays in lymphoma development and shows 100- to 1
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway
CAS Number: 130798-51-5
ACY-1215 (Rocilinostat) - HDAC6 inhibitor. CAS# 1316214-52-4 size:2mg solid 13(9):1070-5ACY 1215 (Rocilinostat), CAS No. 1316214 52 4, is a highly potent, selective, and orally bioavailable inhibitor of histone deacetylase 6 (HDAC6). It inhibits HDAC6 with an enzymatic IC50 ~ 5nM, and has about 10 fold selectivity against HDAC1, HDAC2, and HDAC3 (58 nM, 48 nM, 51 nM). It has minimal activity (IC50 >1 M) against HDAC4, HDAC5, HDAC7, HDAC9, HDAC11, Sirtuin1, and Sirtuin2, and has slight activity against HDAC8 (IC50 ~0. 1 M). ACY 1215
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