Fotemustine cycline (hyclate) Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=C(N)C2=C(F)C=CC=C2NC1=O

Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=C(N)C2=C(F)C=CC=C2NC1=O

is a phosphodiesterase 1 inhibitors useful for treatment of neurological and psychiatric disorder

7)8)48(65)59-25-37(61)23-39(59)47(64)54-29(2)33-9-11-35(12-10-33)44-30(3)53-27-69-44/h9-16

possesses strong antioxidant and cardioprotective properties

Fotemustine cycline (hyclate) Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=C(N)C2=C(F)C=CC=C2NC1=OFotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1 guanine and N3 cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).