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R121919 is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor (Ki=2–5 nM) and over 1000-fold weaker activity at the CRF2 receptor
(R)-HH2853 914CH 50911 R121919 is a potent small-molecule(R) HH2853 is a mutant EZH2 inhibitor with an IC50 of <100 nM for EZH2 Y641F. (R) HH2853 can be used for cancer and autoimmune diseases (WO2018045971A1; compound 201). Product information CAS Number: 2202678 06 4 Molecular Weight: 611. 66 Formula: C31H36F3N7O3 Smiles: CC1=CC=C(N=N1)C1C=CN2C([C@@H](C)N3CCN(CC(F)(F)F)CC3)=C(C)C(=CC2=1)C(=O)NCC1=C(C=C(C)NC1=O)OC InChiKey: BIABSPVTTUDBEO OAQYLSRUSA N InChi: InChI=1S C31H36F3N7O3 c1 18 6 7 25(38 37 18)22 8